Principal Scientist

Description:

Our strategy sets out to bring deeper mechanistic understanding at the molecular and cellular level to all stages of projects, from idea to pre-clinical candidate.

This role is focussed on designing, developing and running of cellular assays to identify, profile and characterise the SAR/SKR of small molecules therapeutics, as well as the bespoke characterisation of their mechanism of action to inform dose prediction and clinical efficacy. As a Principal Scientist within the Cellular Pharmacology team, you will act as a senior member of the project team and discipline group with the expectation of shaping project strategy.

The successful candidate will drive innovative ways of working through keeping abreast of cutting-edge cellular pharmacology techniques and approaches. Furthermore, we actively encourage our colleagues to celebrate our science, by attending conferences, presenting posters, giving talks at events and publishing papers. You might currently be a Principal Scientist or Senior Scientific Officer looking to move into a more patient focused environment, this role will give you the opportunity to form an integral part of the Cancer Research Horizon Drug Discovery team working alongside our industry and academic partners to progress novel cancer targets towards patient benefit.

What are you looking for?

We are seeking an accomplished scientific expert with the following skills and experience:
 

• A BSc, MSc or PhD in biological science; relevant experience may be substituted for education
• Significant experience in a drug discovery environment of characterising targets and their modulation by small molecules through quantitative cell biology
• Demonstrated theoretical and practical understanding of pharmacology and drug-target interactions
• Expertise in assay development across a range of quantitative cell-based assay technologies, with the ability to input across multiple projects both at the lab bench and intellectually
• Experience of liquid handling and automation would be an advantage
• Demonstrated scientific leadership skills with ability to give strategic direction
• Experience of managing the performance and development of line reports
• Credible external reputation, as evidenced though publication, presentation at key conferences, and a strong personal network