Research Fellow

Description:

The University of Warwick invites applications for a Research Fellow to join Dr. Orkun Soyer’s research group in the School of Life Sciences. This Leverhulme Trust-funded position focuses on exploring the role of metabolic co-substrates, particularly NADH, in regulating the respiration-fermentation flux switch. This project combines mathematical modeling with experimental research in yeast, and the appointed researcher will primarily focus on single-cell experimental work.

Key Responsibilities:

• Conduct single-cell experiments related to the respiration-fermentation switch in yeast.
• Test predictions from mathematical models focusing on NADH dynamics and metabolic regulation.
• Utilize quantitative techniques such as fluorescent microscopy, image analysis, microfluidics, metabolomics, and transcriptomics.
• Collaborate with researchers from the University of Warwick and University College London.
• Design and conduct experiments, analyze results, and contribute to research publications.

Required Skills and Qualifications:

• PhD in quantitative biology, cell biology, biochemistry, biophysics, or a related field (applications from candidates nearing PhD submission are welcome).
• Experience in yeast or cell culture experiments.
• Proficiency in fluorescent microscopy, microfluidics, metabolomics, and related techniques.
• Familiarity with experiment design and execution in quantitative biology.

Project Outline:
The project investigates the respiration-fermentation switch seen across microbial and mammalian cells, including cancer cells. By leveraging mathematical models, the research aims to elucidate how co-substrate dynamics, particularly NADH, influence fluxes at metabolic branch points.

About the Research Group:
Dr. Orkun Soyer’s group specializes in quantitative biology, focusing on cell metabolism and metabolic interactions. The group provides a vibrant research environment with state-of-the-art facilities, including a two-photon microscope, -omics platforms, microfluidics, and robotics facilities.

What We Offer:

• Attractive pension scheme
• 30 days of holiday plus Christmas closure
• Onsite childcare facilities
• Flexible working options
• Professional development opportunities, including international conference attendance

Commitment to Diversity:
The University of Warwick is dedicated to creating an inclusive and diverse workplace. They encourage applications from all communities, recognizing and valuing visible and non-visible differences.